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Zyban 150 mg xl and/or Equivalents Bupropion 150 mg xl

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Generic Drug Name Bupropion 150 mg xl
US. Brand Equivalent To Zyban 150 mg xl
Manufacture GLAXOSMITHKLINE , Cipla, Sun
Drug Class Antidepressants
Product Type Prescription Product

Zyban 150 mg xl

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Details

What is bupropion?

Bupropion is an antidepressant medication.

Bupropion or equivalent buy Zyban online, is used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects

Bupropion or cheap Zyban drug may also be used for other purposes not listed in this medication guide.

Important information about bupropion

Do not take bupropion if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. You should not take bupropion if you have seizures, an eating disorder, if you are using a second form of bupropion, or if you have suddenly stopped using alcohol or sedatives.

Bupropion may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

You may have thoughts about suicide when you first start taking an antidepressant such as bupropion, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Before taking bupropion

Do not take bupropion if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

You should not take bupropion if you have:

  • epilepsy or a seizure disorder;

  • an eating disorder such as anorexia or bulimia;

  • if you are using a second form of bupropion; or

  • if you have suddenly stopped using alcohol or sedatives (such as Valium).

Bupropion may cause seizures, especially in people with certain medical conditions. Tell your doctor about all of your medical conditions.

If you have any of these other conditions, your doctor may need to adjust your bupropion dosage or order special tests:

  • a history of head injury, seizures, or brain or spinal cord tumor;

  • heart disease, high blood pressure, history of heart attack;

  • kidney disease;
  • liver disease (especially cirrhosis); or
  • bipolar disorder (manic depression).

You may have thoughts about suicide when you first start taking an antidepressant such as bupropion, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment with bupropion.

FDA pregnancy category C. It is not known whether bupropion will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Bupropion passes into breast milk and could be harmful to a nursing baby. You should not breast-feed while you are taking bupropion. Do not give this medication to anyone younger than 18 years old without the advice of a doctor.

How should I take bupropion?

Buy bupropion online and take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Bupropion can be taken with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time, which could increase side effects including seizures.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.

Your doctor may prescribe nicotine patches or gum to help support your smoking cessation treatment. Be sure you read all directions and safety information for the nicotine product. Using nicotine with Zyban may raise your blood pressure and your doctor may want to check your blood pressure regularly. Do not smoke at any time if you are using a nicotine product along with Zyban. Too much nicotine can cause serious side effects.

Do not stop taking bupropion without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

Bupropion can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking bupropion.

Store bupropion at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose of cheap Bupropion as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.

What should I avoid while taking bupropion?

Drinking alcohol may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

Avoid using bupropion to treat more than one condition at a time. If you take Wellbutrin for depression, do not also take Zyban to quit smoking. Too much of this medicine can increase your risk of a seizure.

Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Bupropion side effects

Get emergency medical help if you have any of these signs of an allergic reaction to bupropion: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect while taking bupropion such as:

  • seizure (convulsions);

  • severe blistering, peeling, and red skin rash;

  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;

  • confusion, trouble concentrating; or

  • hallucinations, unusual thoughts or behavior.

Less serious bupropion side effects may include:

  • headache or migraine;

  • sleep problems (insomnia);

  • nausea, vomiting, constipation, dry mouth;

  • dizziness, tremors (shaking);

  • appetite changes, weight loss or gain;

  • mild itching or skin rash, increased sweating; or

  • loss of interest in sex.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Bupropion side effects (in more detail)

Bupropion Dosing Information

Usual Adult Bupropion Dose for Depression:

Immediate release tablets:
Initial dose: 100 mg orally twice a day.
Maintenance dose: The dosage may be increased in 75 to 100 mg/day increments not more often than every 3 days up to the usual maintenance dose of 100 mg orally 3 times a day. The maximum dose is 450 mg/day, given in 4 divided doses; bupropion should be discontinued if there is not an adequate response to this dose. Single doses should not exceed 150 mg.

Sustained release tablets:
Initial dose: 150 mg orally once a day in the morning.
Maintenance dose: After at least 4 days, the dose may be increased to 100 to 150 mg twice a day. If there is not adequate improvement after several weeks, the dose may be increased to a maximum of 200 mg twice a day.

Extended release tablets (Wellbutrin XL):
Initial dose: 150 mg orally once a day in the morning.
Maintenance dose: After at least 4 days, the dose may be increased to 300 mg once a day. If there is not adequate improvement after several weeks, the dose may be increased to a maximum of 450 mg once a day in the morning.

Extended release tablets (Aplenzin):
Initial dose: 174 mg orally once a day in the morning (equivalent to 150 mg bupropion HCl).
Maintenance dose: After at least 4 days, the dose may be increased to 348 mg once a day (equivalent to 300 mg bupropion HCl). If there is not adequate improvement after several weeks, the dose may be increased to a maximum of 522 mg once a day in the morning (equivalent to 450 mg bupropion HCl).

Usual Adult Bupropion Dose for Smoking Cessation:

Initial Dose: 150 mg orally once a day.
Maintenance: Based on clinical response, this dosage may be increased to 300 mg/day, given as 150 mg twice a day, no sooner than 3 days after beginning therapy.

Usual Adult Bupropion Dose for Seasonal Affective Disorder:

Extended-release:
Initial: 150 mg orally once a day in the morning
Titration: If tolerated, after 7 days dose may be increased to maximum dose of 400 mg once a day administered in the morning. Patients who are unable to tolerate this increase in dose should be reduced back to 150 mg orally once a day.

Usual Geriatric Dose for Depression:

Initial dose: 75 mg orally twice a day.
Maintenance dose: 75 mg orally 3 times a day.
Maximum doses:
Immediate Release: 150 mg orally 3 times a day.
Sustained Release: 400 mg given as 200 mg twice a day.

Usual Pediatric Dose for Attention Deficit Disorder:

Immediate release tablets:
6 to 18 years:
20 to 30 kg: 50 to 150 mg/day in 2 divided doses (investigational).
31 to 40 kg: 75 to 200 mg/day in 2 divided doses (investigational).
Greater than 40 kg: 100 to 250 mg/day in 2 divided doses (investigational).

Extended release tablets:
Less than 11 years: Safety and effectiveness have not been established.
11 to 18 years: 150 to 300 mg/day in 2 divided doses (investigational).

Usual Pediatric Dose for Smoking Cessation:

14 years of age or older and greater than 40.5 Kg:
Hydrochloride salt:
150 mg orally twice a day of sustained release for seven weeks with cessation counseling

What other drugs will affect bupropion?

Many drugs can interact with bupropion. Below is just a partial list. Tell your doctor if you are using:

  • medication used to prevent blood clots, such as clopidogrel (Plavix) or ticlopidine (Ticlid), tirofiban (Aggrastat);

  • cancer medicine such as cyclophosphamide (Cytoxan, Neosar), doxorubicin (Adriamycin, Doxil), irinotecan (Camptosar), or thiotepa (Thioplex);

  • heart or blood pressure medication such as atenolol (Tenormin), flecainide (Tambocor), metoprolol (Lopressor, Toprol), propafenone (Rythmol), propranolol (Inderal), and others; or

  • HIV or AIDS medications such as efavirenz (Atripla, Sustiva) or ritonavir (Norvir, Kaletra).

This list is not complete and there are many other drugs that can interact with bupropion. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. You may have a higher risk of seizures if you use certain medications together with bupropion. Tell your doctor about all other medications you use, especially:

  • any other antidepressant, or a medicine to treat a psychiatric disorder;

  • antihistamines that make you sleepy;

  • asthma medications or bronchodilators;

  • birth control pills or hormone replacement estrogens;

  • bladder or urinary medications such as oxybutynin (Ditropan, Urotrol);

  • antibiotics such as cefdinir (Omnicef), cephalexin (Keflex), ciprofloxacin (Cipro), amoxicillin (Amoxil, Augmentin), penicillin, and others;

  • diet pills, a stimulant, or ADHD medication such as Adderall or Ritalin;

  • insulin or diabetes medications you take by mouth;

  • medication for nausea, vomiting, or motion sickness;

  • medications to treat or prevent malaria;

  • medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma);

  • medicines used to prevent organ transplant rejection;

  • narcotic pain medication;

  • a sedative such as diazepam (Valium), and others;

  • a steroid such as prednisone, and others;

  • street drugs such as "speed" or cocaine;

  • theophylline (Theo-Dur, Slo-Bid, Bronkodyl Theolair, Respbid); or

  • ulcer or irritable bowel medications.

 
    
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